Full Metal Alchemist. The anime that achieved the Best anime award for 2005.
It's now back as FMA Brotherhood and instead of a second season, it is a so called remake as the plot will follow the manga version more closely.
This is the first time I'm watching FMA [thank you animax :)] as I only heard of it.
So here is a trailer.
The anime opening theme. Again by YUI. It rocks.
The anime ending theme."Uso (Lie)" by SID
For those of you who want to know more of the story, go to wikipedia (warning:spoilers).
Those who want to watch, subscribe to animax or fan sub(not recommended)